2 mω tungsten microelectrode  (World Precision Instruments)

Journal: Cell reports

Article Title: Trigeminal innervation and tactile responses in mouse tongue

doi: 10.1016/j.celrep.2024.114665

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Article Snippet: 2 MΩ Tungsten microelectrode , World Precision Instruments , Cat# TM33A20.

Techniques: Virus, Recombinant, Software

Journal: Pain

Article Title: A back-translational study of descending interactions with the induction of hyperalgesia by high-frequency electrical stimulation in rats and humans

doi: 10.1097/j.pain.0000000000003166

Figure Lengend Snippet: High-frequency electrocutaneous stimulation induces secondary pinprick hyperalgesia in humans. (A) Pain intensity ratings to repeated trains of electrical stimulation. (B) Pain intensity ratings to a single-pulse electrical stimulus (primary hyperalgesia). (C) Secondary brush allodynia. (D) Area surrounding the electrode in which stinging, pricking, or sharp sensations were experienced in response to a 10-g von Frey filament. (E) Secondary mechanical pain sensitivity. (F) Secondary mechanical pain threshold. (G) Pain intensity ratings to individual pinprick forces. Data represent mean ± 95% CI; n = 37. * P < 0.05, ** P < 0.01, *** P < 0.001; For panels (A-E), “*” denotes difference from baseline. For panel (G), “*” denotes difference between baseline and 15 minutes time-point (t 15 ), “†” denotes difference between baseline and 45 minutes time-point (t 45 ). BL, baseline; NRS, numerical rating scale.

Article Snippet: Extracellular recordings were obtained from deep dorsal horn wide-dynamic range lamina V/VI neurones with receptive fields on the glabrous skin of the hind toes using 127-µm-diameter 2 MΩ parylene-coated tungsten electrodes (A-M Systems, Sequim, WA).

Techniques:

Journal: Pain

Article Title: A back-translational study of descending interactions with the induction of hyperalgesia by high-frequency electrical stimulation in rats and humans

doi: 10.1097/j.pain.0000000000003166

Figure Lengend Snippet: In CPM responders, applying a distant noxious conditioning stimulus during high-frequency electrocutaneous stimulation has no effect on the development of secondary hyperalgesia in humans. (A) Stratification of subjects based on CPM effect determined by a change in pain detection threshold. Bars represent individual responses, and dashed lines represent standard error of measurement (±8.64). (B) Pain intensity ratings to repeated trains of electrical stimulation with and without conditioning stimulus applied. (C) Pain intensity ratings to a single-pulse electrical stimulus (primary hyperalgesia). (D i ) Area surrounding the electrode in which stinging, pricking, or sharp sensations were experienced in response to a 10-g von Frey filament, and (D ii ) polygon plots of the mean spread of all subjects across experimental sessions. (E) Secondary mechanical pain sensitivity. (F) Secondary mechanical pain threshold. (G) Peak change of pain intensity rating to individual pinprick forces. Data represent mean ± 95% CI; n = 21. * P < 0.05, ** P < 0.01, *** P < 0.001. Unless otherwise indicated, “*” denotes difference between time point and respective baseline. CPM, conditioned pain modulation; CS, conditioning stimulus; HFS, high-frequency stimulation; NRS, numerical rating scale.

Article Snippet: Extracellular recordings were obtained from deep dorsal horn wide-dynamic range lamina V/VI neurones with receptive fields on the glabrous skin of the hind toes using 127-µm-diameter 2 MΩ parylene-coated tungsten electrodes (A-M Systems, Sequim, WA).

Techniques: